Tasmanians are being encouraged to say 'Nup to the Cup' tomorrow, in memory of horses killed each year on racetracks and in slaughter houses.
A recent expose revealed thousands of ex-racehorses were tortured before being killed at abattoirs and knackeries in Australia.
Animal Liberation Tasmania argues the industry is cruel and should be banned.
President Kristy Alger says workers can protest against the race tomorrow.
"It can be difficult at work, but if you don't want to watch the Cup, tell your coworkers your feelings and say no. Or if you're feeling a little more adventurous, you could hold a Nup to the Cup party at work and get your colleagues involved."
She says the sport encourages 'wastage' on a massive scale.
"We could talk about Red Cadeaux, Admire Rakti, Araldo and Verema, the four horses whose lives were ended at the last six Melbourne Cups, but there thousands of horses bred who die every year. There are not enough homes to cater for the amount of horses the industry generates."
She says there are high rates of Exercise-Induced Pulmonary Hemorrhage (bleeding into the lungs and throat) uncovered in a University of Melbourne study, with a staggering 90% of horses showing signs of EIPH post-race.
"These animals are being bred and raced at a young age, leading to increased risks of potentially fatal injury and illness later in their lives," she added.